The implications of FASN in immune cell biology and related diseases.

Yonghong Yang, Huabao Xiong, Yucai Xiao, Guanjun Dong

Journal: Cell death & disease 2024;15(1):88

PMID: 38272906

Free Full Text on Nature Publishing Group View on PubMed

Abstract

Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular physiological process in which nutrients are used for energy storage and biofilm synthesis. As a key enzyme in the fatty acid metabolism, fatty acid synthase (FASN) is receiving increasing attention. Although previous studies on FASN have mainly focused on various malignancies, many studies have recently reported that FASN regulates the survival, differentiation, and function of various immune cells, and subsequently participates in the occurrence and development of immune-related diseases. However, few studies to date systematically summarized the function and molecular mechanisms of FASN in immune cell biology and related diseases. In this review, we discuss the regulatory effect of FASN on immune cells, and the progress in research on the implications of FASN in immune-related diseases. Understanding the function of FASN in immune cell biology and related diseases can offer insights into novel treatment strategies for clinical diseases.

Address: Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.; Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, 272067, Shandong, China.; Jining Key Laboratory of Immunology, Jining Medical University, Jining, 272067, Shandong, China.; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, 272007, Shandong, China.; Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, 272067, Shandong, China. [email protected].; Jining Key Laboratory of Immunology, Jining Medical University, Jining, 272067, Shandong, China. [email protected].; Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, 272067, Shandong, China. [email protected].; Jining Key Laboratory of Immunology, Jining Medical University, Jining, 272067, Shandong, China. [email protected].

DOI: 10.1038/s41419-024-06463-6

Link outs

Free resources

Full Text Sources:

Miscellaneous:

https://assays.cancer.gov/CPTAC-369

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Fatty Acid Synthases, Cell Line, Tumor, Lipogenesis, Lipid Metabolism, Fatty Acids