Immunoregulatory Roles of Osteopontin in Diseases.

Lebei Wang, Xiaoyin Niu

Journal: Nutrients 2024;16(2):

PMID: 38276550

Abstract

Osteopontin (OPN) is a multifunctional protein that plays a pivotal role in the immune system. It is involved in various biological processes, including cell adhesion, migration and survival. The study of the immunomodulatory effects of OPN is of paramount importance due to its potential therapeutic applications. A comprehensive understanding of how OPN regulates the immune response could pave the way for the development of novel treatments for a multitude of diseases, including autoimmune disorders, infectious diseases and cancer. Therefore, in the following paper, we provide a systematic overview of OPN and its immunoregulatory roles in various diseases, laying the foundation for the development of OPN-based therapies in the future.

Address: Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

DOI: 10.3390/nu16020312

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Medical:

https://medlineplus.gov/cancer.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-SPP1-1

MeSH Terms: Humans, Osteopontin, Neoplasms, Cell Adhesion, Immunity