Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges.

Ali Rahnavard, Hui Wen, Kevin C Klatt, Emily R Smith, Sabina Mugusi, Ranojoy Chatterjee, Clark Gaylord

Journal: Journal of translational medicine 2024;22(1):106

PMID: 38279125

Abstract

Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to study further. Here we discuss overall trends and examples of successfully using omics technologies and techniques (e.g., genomics, proteomics, metabolomics, and metagenomics) to investigate the molecular epidemiology of pregnancy. In addition, we outline omics applications and study characteristics of pregnancy for understanding fundamental biology, causal health, and physiological relationships, risk and prediction modeling, diagnostics, and correlations.

© 2024. The Author(s).

Address: Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, Washington, DC, 20052, USA. [email protected].; Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Washington, DC, 20052, USA. [email protected].; Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, Washington, DC, 20052, USA.; Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Washington, DC, 20052, USA.; Department of Clinical Pharmacology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.; Nutritional Sciences & Toxicology, University of California, Berkeley, CA, 94720, USA.; Department of Global Health, The Milken Institute School of Public Health, The George Washington University, Washington, DC, 20052, USA. [email protected].; Department of Exercise and Nutrition Sciences, The Milken Institute School of Public Health, The George Washington University, Washington, DC, 20052, USA. [email protected].
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