Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities.

Thoraya A Farghaly, Ghaidaa H Alfaifi, Sobhi M Gomha

Journal: Mini reviews in medicinal chemistry 2024;24(2):196-251

PMID: 37496137

Abstract

The thiazole ring is naturally occurring and is primarily found in marine and microbial sources. It has been identified in various compounds such as peptides, vitamins (thiamine), alkaloids, epothilone, and chlorophyll. Thiazole-containing compounds are widely recognized for their antibacterial, antifungal, anti-inflammatory, antimalarial, antitubercular, antidiabetic, antioxidant, anticonvulsant, anticancer, and cardiovascular activities. The objective of this review is to present recent advancements in the discovery of biologically active thiazole derivatives, including their synthetic methods and biological effects. This review comprehensively discusses the synthesis methods of thiazole and its corresponding biological activities within a specific timeframe, from 2017 until the conclusion of 2022.

Address: Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukaramah, 21514, Saudi Arabia.; Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia.; Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt.

DOI: 10.2174/1389557523666230726142459

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MeSH Terms: Thiazoles, Antimalarials, Thiamine, Antitubercular Agents, Antifungal Agents, Structure-Activity Relationship