MicroRNA Profiles in Critically Ill Patients.

Babak Alikiaii, Rajkumar Rajendram, Mohammad Bagherniya, Gholamreza Askari, Amirhossein Sahebkar

Journal: Current medicinal chemistry 2024;31(41):6801-6825

PMID: 37496239

Full Text on Bentham Science Publishers Ltd. View on PubMed

Abstract

The use of biomarkers to expedite diagnosis, prognostication, and treatment could significantly improve patient outcomes. The early diagnosis and treatment of critical illnesses can greatly reduce mortality and morbidity. Therefore, there is great interest in the discovery of biomarkers for critical illnesses. Micro-ribonucleic acids (miRNAs) are a highly conserved group of non-coding RNA molecules. They regulate the expression of genes involved in several developmental, physiological, and pathological processes. The characteristics of miRNAs suggest that they could be versatile biomarkers. Assay panels to measure the expression of several miRNAs could facilitate clinical decision-- making for a range of diseases. We have, in this paper, reviewed the current understanding of the role of miRNAs as biomarkers in critically ill patients.

Address: Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.; Department of Medicine, King Abdulaziz Medical City, King Abdulaziz International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.; College of Medicine, King Saud bin Abdulaziz University of Health Sciences, Riyadh, Saudi Arabia.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.2174/0929867331666230726095222

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MeSH Terms: Humans, Critical Illness, MicroRNAs, Biomarkers