Mapping the landscape of immunonutrition and cancer research: a comprehensive bibliometric analysis on behalf of NutriOnc Research Group.

Raffaele De Luca, Maria G Rodriquenz, Dario Parini, Roberta La Mendola, Gianmario E Poto, Carlo G Cattaneo, Francesca De Felice, Luigi Marano, Ludovico Carbone, Antonio Brillantino, Lorena Incorvaia, Viola Salvestrini, Isacco Desideri, Federica Marmorino, Federica Sebastiani, Carmine Antropoli, Oronzo Brunetti, Karol Polom

Journal: International journal of surgery (London, England) 2024;110(1):395-405

PMID: 37737933

Abstract

The ongoing global health challenge of cancer is driving the pursuit of innovative avenues for prevention, treatment, and enhanced outcomes. The convergence of nutrition and immune modulation, known as immunonutrition, is ready to act as a catalyst for transformative change in cancer research and therapy. Our study employs a bibliometric analysis to uncover the evolving trends within immunonutrition and cancer research across the past 25 years. Bibliometric data, including authors, journals, affiliations, and countries, were analyzed using the Bibliometrix R package. Clustering algorithms were applied to keywords to identify thematic areas and their evolution. A total of 489 documents were analyzed, showing an annual growth rate of 8.7%, with a collaboration index of 5.41, highlighting comprehensive multidisciplinary involvement within this landscape. Core authors demonstrated sustained productivity, while occasional authors indicated widespread interest. The Medical University of Warsaw led in institutional contributions. Country-wise, Italy, France, and the USA emerged as forerunners in fostering research productivity. Key journals like 'Clinical Nutrition' served as beacons, emphasizing the multidimensional nature of this topic. The analysis highlighted growing research output and several collaborations, indicating the importance of immunoenriched nutrition in cancer treatment. The interplay of core authors and diversified engagement harmoniously accentuates the cross-disciplinary nature of this burgeoning field. International collaboration facilitated knowledge exchange. Prominent documents shaped the field, emphasizing the significance of nutritional interventions. Thematic clusters revealed varied focuses, including pharmaconutrients, surgical approaches, inflammation, and specific cancers. The expanding research output suggests further development, particularly in exploring immunoenriched nutrition's impact on cancer types and patient populations. The multidisciplinary nature and international collaborations enhance the field's progress. Gaps in research underscore the need for original studies and personalized approaches. This study guides future research, informing evidence-based nutritional interventions and advancing cancer care practices.

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

Address: Department of Radiotherapy, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome.; Italian Registry of Physicians and Surgeons, Regione Campania, Italy.; 3rd Division of General Surgery, "A. Cardarelli" Hospital, Naples.; Department of Surgical Oncology IRCCS Istituto Tumori "Giovanni Paolo II"-Bari.; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence.; Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo.; General and Upper GI Surgery Division, University of Verona, P.zza Aristide Stefani, Verona.; Unit of Oncology, University Hospital of Pisa Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa.; General Surgery Unit, Santa Maria della Misericordia Hospital, Rovigo.; Unit of Oncology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Foggia.; CyberKnife Center, Istituto Fiorentino di Cura ed Assistenza (IFCA), Radiation Oncology.; Radiation Oncology Unit, Oncology Department, Careggi University Hospital, Florence.; Section of Clinical Nutrition, AUSL - IRCCS Reggio Emilia, Reggio Emilia, Italy.; Clinic of Oncological, Transplantation and General Surgery, Gdansk Medical University, Gdansk.; Academy of Applied Medical and Social Sciences - AMiSNS: Akademia Medycznych i Spolecznych Nauk Stosowanych - 2 Lotnicza street, Elbląg, Poland.
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