OMERACT 2023 Systemic Lupus Erythematosus Special Interest Group: Winnowing and Binning Preliminary Candidate Domains for the Core Outcome Set.

Kimberly Trotter, Juanita Romero-Diaz, Julian Thumboo, Amita Aggarwal, Marta Mosca, Wils Nielsen, Alfred H J Kim, Maya Desai, Yvonne Enman, Yashaar Chaichian, Sandra Navarra, Oshrat E Tayer-Shifman, Lai Shan Tam, Guillermo J PonsEstel, Alberta Hoi, Danaë Papachristos, Aaron Howe, Behdin Nowrouzi Kia, Dennisse Bonilla, Vibeke Strand, Aaron M Drucker, Keishi Fujio, Zahi Touma, Meggan MacKay, Rosalind Ramsey-Goldman, Sindhu R Johnson, Martin Aringer, Ian Bruce, Manuel F Ugarte-Gil, Eric Morand, John A Reynolds, Daniel Wallace, Ali Duarte-Garcia, Mandana Nikpour, Ioannis Parodis, Lee S Simon, Chi Chiu Mok, Cynthia Aranow

Journal: Seminars in arthritis and rheumatism 2024;65():152380

PMID: 38281467

Abstract

BACKGROUND

The Outcome Measures in Rheumatology (OMERACT) Systemic Lupus Erythematosus (SLE) Working Group held a Special Interest Group (SIG) at the OMERACT 2023 conference in Colorado Springs where SLE collaborators reviewed domain sub-themes generated through qualitative research and literature review.

OBJECTIVE

The objective of the SIG and the subsequent meetings of the SLE Working Group was to begin the winnowing and binning of candidate domain sub-themes into a preliminary list of candidate domains that will proceed to the consensus Delphi exercise for the SLE COS.

METHODS

Four breakout groups at the SLE SIG in Colorado Springs winnowed and binned 132 domain sub-themes into candidate domains, which was continued with a series of virtual meetings by an advisory group of SLE patient research partners (PRPs), members of the OMERACT SLE Working Group Steering Committee, and other collaborators.

RESULTS

The 132 domain sub-themes were reduced to a preliminary list of 20 candidate domains based on their clinical and research relevance for clinical trials and research studies.

CONCLUSION

A meaningful and substantial winnowing and binning of candidate domains for the SLE COS was achieved resulting in a preliminary list of 20 candidate domains.

Copyright © 2024. Published by Elsevier Inc.

Address: University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada.; Division of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto, California, USA.; SDG, LLC, Cambridge, Massachusetts, USA.; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;; Department of Gastroenterology, Dermatology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Faculty of Design, OCAD University, Toronto, Ontario, Canada.; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;; Swedish Rheumatism Association, Stockholm, Sweden.; Division of Rheumatology, Department of Medicine, Cedars-Sinai; David Geffen School of Medicine at UCLA, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA.; Department of Rheumatology, University of Santo Tomas Hospital, Manila, Philippines.; Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Feinstein Institutes for Medical Research, Manhasset, New York, USA.; Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois, USA.; Rheumatology Unit, Meir Medical Center, Kfar Saba, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Division of Rheumatology, Mayo Clinic, Rochester, MN.; Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.; Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas. Universidad Cientifica del Sur, Lima, Peru; Rheumatology Department. Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru.; Grupo Oroño - Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina.; Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, 1724University of Birmingham, Birmingham, UK.; The University of Sydney School of Public Health, Camperdown, NSW, 2006, Australia.; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Melbourne, Australia.; Instituto Nacional de Ciencias Médicas y Nutricion, México City, México.; Department of Rheumatology, Mater Hospital, Brisbane, Australia.; Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.; Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China.; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Restore Lab, Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON M5G 1V7, Canada.; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore.; Department of Clinical and Experimental Medicine, University of Pisa, Italy.; Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany.; Toronto Western Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada.; Division of Dermatology, Department of Medicine, University of Toronto and Women's College Hospital.; Centre for Inflammatory Disease, Monash University, Melbourne, Australia.; Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.; University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada. Electronic address: [email protected].
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