Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia.

Peipei Xu, Ying Du, Yue Chen, Zhenyu Liu, Mengge Pan, Lanxin Chen, Miaoxin Peng, Yiran Fang, Yonggong Yang

Journal: Annals of hematology 2024;103(4):1181-1185

PMID: 38294534

Abstract

Acute promyelocytic leukemia (APL) is a specific subtype of acute myeloid leukemia that is distinguished by the chromosomal translocation t(15;17)(q24;q21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARA). Recently, we identified a novel fusion gene in APL, RARA::ankyrin repeat domain 34C (ANKRD34C), identified its functions by morphological, cytogenetic, molecular biological and multiplex fluorescence in situ hybridization analyses, and demonstrated the potential therapeutic effect clinically and experimentally of all-trans retinoic acid (ATRA); the findings have important implications for the diagnosis and treatment of atypical APL.

Address: Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, 210008, China.; Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.; Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China. [email protected].; Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China. [email protected].

DOI: 10.1007/s00277-024-05629-8

Link outs

Subscription / membership required

Full Text Sources:

https://dx.doi.org/10.1007/s00277-024-05629-8

MeSH Terms: Humans, Leukemia, Promyelocytic, Acute, In Situ Hybridization, Fluorescence, Tretinoin, Retinoic Acid Receptor alpha, Carrier Proteins, Translocation, Genetic, Oncogene Proteins, Fusion