Post-translational mechanisms in psychostimulant-induced neurotransmitter efflux.

Christopher R Brown, L Keith Henry, Roxanne A Vaughan, James D Foster

Journal: Advances in pharmacology (San Diego, Calif.) 2024;99():1-33

PMID: 38467478

Full Text on Elsevier Science View on PubMed

Abstract

The availability of monoamine neurotransmitters in the brain is under the control of dopamine, norepinephrine, and serotonin transporters expressed on the plasma membrane of monoaminergic neurons. By regulating transmitter levels these proteins mediate crucial functions including cognition, attention, and reward, and dysregulation of their activity is linked to mood and psychiatric disorders of these systems. Amphetamine-based transporter substrates stimulate non-exocytotic transmitter efflux that induces psychomotor stimulation, addiction, altered mood, hallucinations, and psychosis, thus constituting a major component of drug neurochemical and behavioral outcomes. Efflux is under the control of transporter post-translational modifications that synergize with other regulatory events, and this review will summarize our knowledge of these processes and their role in drug mechanisms.

Address: Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, United States. Electronic address: [email protected].; Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, United States.

DOI: 10.1016/bs.apha.2023.10.003

Link outs

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1054...

MeSH Terms: Humans, Amphetamine, Biological Transport, Dopamine, Neurotransmitter Agents, Protein Processing, Post-Translational