Prevalence of ocular toxoplasmosis among people living with HIV: a systematic review and meta-analysis.

Athanasios Tsakris, Maria Kantzanou, Fotini Boufidou, Evangelos Kostares, Georgia Kostare, Antzela Tzanai, Michael Kostares

Journal: Future microbiology 2024;19(6):525-534

PMID: 38507297

Abstract

To determine the prevalence of ocular toxoplasmosis among people living with HIV through a systematic review and meta-analysis. A literature search was conducted, estimating pooled prevalence and performing quality assessment, outlier, influential and meta-regression analyses. Twenty-nine studies were included in the analysis, revealing that the rate of ocular toxoplasmosis among people living with HIV was 0.37% (95% CI: 0.2-0.6). Substantial heterogeneity was observed among the studies. Despite analyzing continuous variables, including year of publication, proportion of males, mean age and proportion of patients receiving antiretroviral therapy, no statistically significant associations were found. This study provides an overview of the prevalence of ocular toxoplasmosis in people living with HIV, emphasizing the need for further research to uncover factors contributing to its development.

Address: Department of Microbiology, Medical School, National & Kapodistrian University of Athens, Athens, 11527, Greece.; Neurochemistry & Biological Markers Unit, 1st Department of Neurology, Eginition Hospital, Medical School, National & Kapodistrian University of Athens, Athens, 11528, Greece.

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