Brunner's gland hamartomas: Not always benign.

Manar Shmais, Ala I Sharara, Ahmad Mousawi, Fadi Mourad

Journal: Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024;25(1):70-73

PMID: 38296695

Full Text on Elsevier Science View on PubMed

Abstract

Brunner's gland hamartoma (BGH) is a rare, benign tumor of the duodenum. It is mostly asymptomatic and usually found incidentally on routine esophagogastroduodenoscopy (EGD). However, some BGHs present with major complications including anemia, bleeding, obstruction, or dysplasia, requiring management and resection of these lesions. Herein, we present two cases of large BGHs of the duodenum, one presenting as severe gastrointestinal bleeding and the other, noted on EGD for iron deficiency anemia, found to have high grade dysplasia. This literature review discusses the rare serious complications of BGH, including iron deficiency anemia, overt gastrointestinal bleeding, and malignant potential.

Address: Division of Gastroenterology and Hepatology, Saint Louis University Hospital, MO, USA. Electronic address: [email protected].; Division of Gastroenterology and Hepatology, American University of Beirut, Beirut, Lebanon. Electronic address: [email protected].; Division of Gastroenterology and Hepatology, American University of Beirut, Beirut, Lebanon. Electronic address: [email protected].; Division of Gastroenterology and Hepatology, American University of Beirut, Beirut, Lebanon. Electronic address: [email protected].

DOI: 10.1016/j.ajg.2023.12.003

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MeSH Terms: Humans, Brunner Glands, Duodenal Diseases, Anemia, Iron-Deficiency, Hamartoma, Gastrointestinal Hemorrhage