Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis.

Address: Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Paris, France.; Imagine Institute, University of Paris , Paris, France.; Clinical Immunology Department, Assistance Publique Hôpitaux de Paris (AP-HP), Saint-Louis Hospital, Paris, France.; Department of Dermatology and INSERM 1098, University of Bourgogne-Franche Comté, Besançon, France.; Genomic Medicine Institute, Cleveland Clinic Foundation , Cleveland, OH, USA.; Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Cleveland Clinic, Cleveland, OH, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Department of Paediatric Infectious Diseases and Virology, Imperial College London, London, UK.; Imperial College London, Centre for Paediatrics and Child Health , London, UK.; Department of Pediatrics, Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, NY, USA.; Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH, USA.; Weill Cornell Medicine , New York, NY, USA.; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Center for Personalized Genetic Healthcare, Cleveland Clinic Foundation , Cleveland, OH, USA.; Imagine Institute, University of Paris , Paris, France.; Laboratory of Genetic Skin Diseases, INSERM U1163, Paris, France.; Université Paris-Cité , Paris, France.; Paediatric Hematology-Immunology and Rheumatology Unit, Hopital Necker-Enfants Malades, Assistance Publique-Hopitaux de Paris, Paris, Fance.; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Paris, France.; Imagine Institute, University of Paris , Paris, France.; Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children , Paris, France.; Department of Immunology, Derriford Hospital, Plymouth, UK.; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Columbia University Irving Medical Center , New York, NY, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Division of Immunology, Allergy, and Retrovirology, Texas Children's Hospital, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine , Houston, TX, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Paris, France.; Imagine Institute, University of Paris , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute , New Yor, NY, USA.; Department of Pediatrics, Necker Hospital for Sick Children, Paris, France.; Department of Medicine, Division of Genomic Medicine, Icahn School of Medicine at Mount Sinai, Institute for Genomic Health, New York, NY, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Paris, France.; Imagine Institute, University of Paris , Paris, France.; Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA.; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pediatrics, Hiroshima University, Hiroshima, Japan.