The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers.

Kiyan Heshmat-Ghahdarijani, Mehrdad Rabiee Rad, Ghazal Ghasempour Dabaghi, Mahtab Mohammad-Zamani, Atieh Karimi Shervedani, Farnaz Bahrami-Samani

Journal: Current problems in cancer 2024;48():101063

PMID: 38330781

Full Text on Elsevier Science View on PubMed

Abstract

Currently, several options are available for the prevention and treatment of cancers; however, many limitations remain with these approaches. Recently, antioxidants have become important preventive and therapeutic alternatives with few adverse events and minimum cost. Coenzyme Q10 (CoQ10) is a naturally occurring component that performs an anticancer function by reducing oxidative stress. CoQ10 supplementation as an adjuvant therapy offers more progress in the elimination and development of cancers. This review aimed to critically assess and summarize the implication of CoQ10 in cancers, highlighting possible mechanisms, and future directions of research for the standardization of the current regimen for cancer prevention and treatment.

Address: School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.; Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Shahid Rahmani Alley, Moshtagh Sevom St., Isfahan, Iran. Electronic address: [email protected].

DOI: 10.1016/j.currproblcancer.2024.101063

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MeSH Terms: Humans, Ubiquinone, Antioxidants, Oxidative Stress, Neoplasms