Clinical potential of fasting in type 1 diabetes.

Mary-Claire Runchey, Lisa S Chow, Alaina P Vidmar, Krista A Varady, Sirimon Reutrakul

Journal: Trends in endocrinology and metabolism: TEM 2024;35(5):413-424

PMID: 38331668

Full Text on Elsevier Science View on PubMed

Abstract

Most adults with type 1 diabetes (T1DM) are either overweight or obese. As such, dietary management is recommended as an adjunct to insulin treatment to improve glycemic control and facilitate weight loss in these patients. Time-restricted eating (TRE) is a form of intermittent fasting that offers a simplified approach to treating obesity in T1DM. TRE typically involves restricting eating to 6 to 10 h per day, with water and medications allowed outside the eating window. This review examines the efficacy of TRE and other fasting protocols in improving weight and glycemic control in patients with obesity and T1DM. This review will also evaluate the safety of these regimens and provide advice to clinicians on implementing intermittent fasting in T1DM.

Address: Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA. Electronic address: [email protected].; Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, and Department of Biobehavioral Nursing Science, University of Illinois Chicago, Chicago, IL, USA.; Children's Hospital Los Angeles and Keck School of Medicine of the University of Southern California, Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Los Angeles, CA, USA.; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minnesota, MN, USA.

DOI: 10.1016/j.tem.2024.01.007

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MeSH Terms: Humans, Diabetes Mellitus, Type 1, Fasting, Obesity