Chitosan-based nanofibrous scaffolds for biomedical and pharmaceutical applications: A comprehensive review.

Fahad Alsaikhan, Sivasankaran Ponnusankar, Asghar Narmani, Yasir Qasim Almajidi, Bagher Farhood, M V N L Chaitanya, Mohamed J Saadh, Chou-Yi Hsu, Arya Lakshmi Marisetti, Aya Mohammed Dhiaa, Yogendra Pal, Russul Thabit, Ayat Hussein Adhab

Journal: International journal of biological macromolecules 2024;264(Pt 2):130683

PMID: 38458289

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Abstract

Nowadays, there is a wide range of deficiencies in treatment of diseases. These limitations are correlated with the inefficient ability of current modalities in the prognosis, diagnosis, and treatment of diseases. Therefore, there is a fundamental need for the development of novel approaches to overcome the mentioned restrictions. Chitosan (CS) nanoparticles, with remarkable physicochemical and mechanical properties, are FDA-approved biomaterials with potential biomedical aspects, like serum stability, biocompatibility, biodegradability, mucoadhesivity, non-immunogenicity, anti-inflammatory, desirable pharmacokinetics and pharmacodynamics, etc. CS-based materials are mentioned as ideal bioactive materials for fabricating nanofibrous scaffolds. Sustained and controlled drug release and in situ gelation are other potential advantages of these scaffolds. This review highlights the latest advances in the fabrication of innovative CS-based nanofibrous scaffolds as potential bioactive materials in regenerative medicine and drug delivery systems, with an outlook on their future applications.

Address: Department of Pharmacy, Baghdad College of Medical Sciences, Baghdad, Iraq.; Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, The Nilgiris, India.; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India.; Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi 110017, India.; Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan. Electronic address: [email protected].; Department of Pharmacy, Al-Noor University College, Nineveh, Iraq.; Faculty of Pharmacy, Middle East University, Amman 11831, Jordan.; Department of Pharmaceutical Chemistry, CT College of Pharmacy, Shahpur, Jalandhar, Punjab 144020, India.; Medical Technical College, Al-Farahidi University, Iraq.; Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq.; College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia; School of Pharmacy, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia. Electronic address: [email protected].; Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran. Electronic address: [email protected].; Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected].

DOI: 10.1016/j.ijbiomac.2024.130683

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MeSH Terms: Chitosan, Pharmaceutical Preparations, Nanofibers, Biocompatible Materials, Tissue Scaffolds, Tissue Engineering