Pathophysiology of Eosinophilic Esophagitis.

Melanie A Ruffner, Amanda B Muir, Kanak V Kennedy

Journal: Immunology and allergy clinics of North America 2024;44(2):119-128

PMID: 38575212

Full Text on Elsevier Science View on PubMed

Abstract

Eosinophilic esophagitis (EoE) is a chronic, progressive immune-mediated disease associated with antigen-driven type 2 inflammation and symptoms of esophageal dysfunction. Research over the last 2 decades has dramatically furthered our understanding of the complex interplay between genetics, environmental exposures, and cellular and molecular interactions involved in EoE. This review provides an overview of our current understanding of EoE pathogenesis.

Address: Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Abramson Research Center 902E, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: [email protected].; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Abramson Research Center 902E, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA; Division of Pediatric Allergy and Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia.

DOI: 10.1016/j.iac.2023.12.001

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MeSH Terms: Humans, Eosinophilic Esophagitis, Inflammation