Natural products for combating multidrug resistance in cancer.

Juan Su, Dong-Hua Yang, Ting Chen, Xuan Yao, Fei Ye, Yun Wang, Xiaoyan Liu, Zhicheng Xiao, Tingfang Wang, Liyan Xiong

Journal: Pharmacological research 2024;202():107099

PMID: 38342327

Free Full Text on Elsevier Science View on PubMed

Abstract

Cancer cells frequently develop resistance to chemotherapeutic therapies and targeted drugs, which has been a significant challenge in cancer management. With the growing advances in technologies in isolation and identification of natural products, the potential of natural products in combating cancer multidrug resistance has received substantial attention. Importantly, natural products can impact multiple targets, which can be valuable in overcoming drug resistance from different perspectives. In the current review, we will describe the well-established mechanisms underlying multidrug resistance, and introduce natural products that could target these multidrug resistant mechanisms. Specifically, we will discuss natural compounds such as curcumin, resveratrol, baicalein, chrysin and more, and their potential roles in combating multidrug resistance. This review article aims to provide a systematic summary of recent advances of natural products in combating cancer drug resistance, and will provide rationales for novel drug discovery.

Address: Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China.; School of Pharmacy, Naval Medical University, Shanghai 200433, China. Electronic address: [email protected].; Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address: [email protected].; Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address: [email protected].; New York College of Traditional Chinese Medicine, NY 11501, USA. Electronic address: [email protected].

DOI: 10.1016/j.phrs.2024.107099

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https://linkinghub.elsevier.com/retrieve/pii/S1043...

Medical:

https://medlineplus.gov/cancer.html

MeSH Terms: Humans, Antineoplastic Agents, Biological Products, Neoplasms, Drug Resistance, Multiple, Drug Resistance, Neoplasm