Unraveling lipid metabolism reprogramming for overcoming drug resistance in melanoma.

Jinfeng Wu, Qin Yan, Xiao Liu, Ruilong Wang

Journal: Biochemical pharmacology 2024;223():116122

PMID: 38467377

Full Text on Elsevier Science View on PubMed

Abstract

Cutaneous melanoma is the deadliest form of skin cancer, and its incidence is continuing to increase worldwide in the last decades. Traditional therapies for melanoma can easily cause drug resistance, thus the treatment of melanoma remains a challenge. Various studies have focused on reversing the drug resistance. As tumors grow and progress, cancer cells face a constantly changing microenvironment made up of different nutrients, metabolites, and cell types. Multiple studies have shown that metabolic reprogramming of cancer is not static, but a highly dynamic process. There is a growing interest in exploring the relationship between melanoma andmetabolic reprogramming, one of which may belipid metabolism. This review frames the recent research progresses on lipid metabolism in melanoma.In addition, we emphasize the dynamic ability of metabolism during tumorigenesis as a target for improving response to different therapies and for overcoming drug resistance in melanoma.

Address: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.; Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: [email protected].; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: [email protected].

DOI: 10.1016/j.bcp.2024.116122

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MeSH Terms: Humans, Melanoma, Skin Neoplasms, Lipid Metabolism, Metabolic Reprogramming, Drug Resistance, Lipids, Tumor Microenvironment