Current state of the epilepsy drug and device pipeline.

Jacqueline A French, Samuel W Terman, Laura Kirkpatrick, Lisa F Akiyama, Wadih Baajour, Deniz Atilgan, Maria Kristina C Dorotan, Hyoung Won Choi

Journal: Epilepsia 2024;65(4):833-845

PMID: 38345387

Abstract

The field of epilepsy has undergone substantial advances as we develop novel drugs and devices. Yet considerable challenges remain in developing broadly effective, well-tolerated treatments, but also precision treatments for rare epilepsies and seizure-monitoring devices. We summarize major recent and ongoing innovations in diagnostic and therapeutic products presented at the seventeenth Epilepsy Therapies & Diagnostics Development (ETDD) conference, which occurred May 31 to June 2, 2023, in Aventura, Florida. Therapeutics under development are targeting genetics, ion channels and other neurotransmitters, and many other potentially first-in-class interventions such as stem cells, glycogen metabolism, cholesterol, the gut microbiome, and novel modalities for delivering electrical neuromodulation.

© 2024 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

Address: University of Michigan Department of Neurology, Ann Arbor, Michigan, USA.; University of Pittsburgh Department of Neurology, Pittsburgh, Pennsylvania, USA.; University of Pittsburgh Department of Pediatrics, Pittsburgh, Pennsylvania, USA.; University of Washington Department of Neurology, Seattle, Washington, USA.; Department of Neurology, University of Texas Health Science Center at Houston, Houston, Texas, USA.; Department of Neurology and WVU Medicine Children's Hospital, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.; Department of Neurology, University of Texas Health Science Center at Houston, Houston, Texas, USA.; Yale University Department of Neurology, New Haven, Connecticut, USA.; Division of Neurology, Emory University Department of Pediatrics, Atlanta, Georgia, USA.; NYU Grossman School of Medicine and NYU Langone Health, New York, New York, USA.
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