Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Mohammad Ali Goudarzi, Cain C T Clark, Saeed Nosratabadi, Zahra Sohrabi, Neda Haghighat, Zahra Namkhah, Mohammad Hashem Hashempur

Journal: Current drug targets 2024;25(2):121-134

PMID: 38141198

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Abstract

INTRODUCTION

There is a growing interest in the considerable benefits of grape products intake, as some studies have indicated that they may improve cardiometabolic risk factors. However, the widespread impact of grape products on the anthropometric indices is not fully resolved.

METHOD

The purpose of this systematic review and meta-analysis was to examine the effects of grape products intake on anthropometric indices in adults. Randomized controlled trials (RCT) examining the effects of grape products intake on anthropometric indices, published up to December 2021, were identified through PubMed, SCOPUS, and ISI Web of Science databases. 30 studies with 35 effect sizes, including 1284 participants (708 cases and 576 controls), were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence interval (CI).

RESULT

The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.

CONCLUSION

Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.

Address: Department of Nutrition, Islamic Azad University, Shahrekord, Iran.; Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz 0098, Iran.; Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran.; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, U.K.; Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

DOI: 10.2174/0113894501272740231219072525

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MeSH Terms: Humans, Randomized Controlled Trials as Topic, Vitis, Obesity, Adult, Body Weight, Body Mass Index, Grape Seed Extract