Advancing glioblastoma treatment by targeting metabolism.

Mengyu Liu, Xuemei Ma, Fei Xie, Jinyi Zhao, Peixian Gao, Xueqi Han, Pengxiang Zhao

Journal: Neoplasia (New York, N.Y.) 2024;51():100985

PMID: 38479191

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Abstract

Alterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism reprogramming have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, it is becoming increasingly important to explore the role of internal and external factors in metabolic regulation in order to identify more precise therapeutic targets and diagnostic markers for GBM. In this review, we define the metabolic characteristics of GBM, investigate metabolic specificities such as targetable vulnerabilities and therapeutic resistance, as well as present current efforts to target GBM metabolism to improve the standard of care.

Address: College of Chemistry and Life Science, Beijing University of Technology, Beijing, China; Beijing Molecular Hydrogen Research Center, Beijing, China.; College of Chemistry and Life Science, Beijing University of Technology, Beijing, China; Beijing Molecular Hydrogen Research Center, Beijing, China. Electronic address: [email protected].

DOI: 10.1016/j.neo.2024.100985

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MeSH Terms: Humans, Glioblastoma, Brain Neoplasms, Cell Line, Tumor