Alterations in exocrine pancreatic function after acute pancreatitis.

Anna Evans Phillips, Joseph Bejjani, Phil A Hart, Mitchell L Ramsey, Vikesh K Singh, Peter J Lee, Dhiraj Yadav, Georgios I Papachristou

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2024;24(4):505-510

PMID: 38485543

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Abstract

Exocrine pancreatic dysfunction (EPD) is a malabsorptive complication of pancreatic disorders that can lead to a host of symptoms ranging from flatulence to diarrhea and contribute to weight loss and metabolic bone disease. It is increasingly recognized to occur after acute pancreatitis (AP), including episodes with mild severity. The risk of developing EPD after AP is influenced by a range of factors, including the degree of acinar cell destruction and inflammation during AP, and persistent structural derangements following AP. In this article, we discuss the epidemiology, pathophysiology, and clinical management of EPD after AP while highlighting key knowledge gaps.

Address: Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Division of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: [email protected].

DOI: 10.1016/j.pan.2024.03.003

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MeSH Terms: Humans, Pancreatitis, Pancreas, Exocrine, Exocrine Pancreatic Insufficiency, Acute Disease