Direct radiolabeling of methotrexate and methotrexate micelles with Tc-99m using QbD approach.

Prashant G Upadhaya, Swapna J Nabar

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2024;209():111313

PMID: 38603864

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Abstract

The aim of the work presented in this manuscript was to radiolabel methotrexate and prepare radiolabeled methotrexate micelles, an antifolate drug with Tc-99m using QbD approach. The radiolabeling was executed using the experimental design and the radiolabeled drug was further encapsulated in micelles. The authors are of the view that the radiolabeled MTX could be used to target the folate receptor overexpressing cancers such as the kidney, colorectal, breast, brain etc thereby opening newer possibilities to the theranostic applications of the formed conjugate.

Address: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India.; Radiation Medicine Centre, Bhabha Atomic Research Centre, Annex Building, Tata Memorial Hospital Campus, JerbaiWadia Road, Dadar East, Mumbai, 400012, India. Electronic address: [email protected].

DOI: 10.1016/j.apradiso.2024.111313

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MeSH Terms: Methotrexate, Micelles, Technetium, Humans, Radiopharmaceuticals, Isotope Labeling, Folic Acid Antagonists