Exercise training mode effects on myokine expression in healthy adults: A systematic review with meta-analysis.

Francesco Bettariga, Valentina Natalucci, Pedro Lopez, Daniel A Galvão, Dennis R Taaffe, Jin-Soo Kim, Robert U Newton, Chris Bishop, Anna Maria Markarian

Journal: Journal of sport and health science 2024;13(6):764-779

PMID: 38604409

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Abstract

BACKGROUND

The benefits of exercise are well known; however, many of the underlying molecular mechanisms are not fully understood. Skeletal muscle secretes myokines, which mediate muscle-organ crosstalk. Myokines regulate satellite-cell proliferation and migration, inflammatory cascade, insulin secretion, angiogenesis, fatty oxidation, and cancer suppression. To date, the effects of different exercise modes (namely, aerobic and resistance exercise) on myokine response remain to be elucidated. This is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical treatment.

METHODS

A systematic search was undertaken in PubMed, MEDLINE, CINAHL, Embase, SPORTDiscus, and Web of Science in April 2023. Eligible studies examining the effects of a single bout of exercise on interleukin15 (IL-15), irisin, secreted protein acidic and rich in cysteine (SPARC), oncostatin M (OSM), and decorin were included. A random-effects meta-analysis was also undertaken to quantify the magnitude of change.

RESULTS

Sixty-two studies were included (n = 1193). Overall, exercise appeared to induce small to large increases in myokine expression, with effects observed immediately after to 60 min post-exercise, although these were mostly not statistically significant. Both aerobic and resistance exercise resulted in changes in myokine levels, without any significant difference between training modes, and with the magnitude of change differing across myokines. Myokine levels returned to baseline levels within 180 min to 24 h post-exercise. However, owing to potential sources of heterogeneity, most changes were not statistically significant, indicating that precise conclusions cannot be drawn.

CONCLUSION

Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic circulation. Further research is required to investigate the effects of different exercise modes at multiple time points on myokine response.

Address: Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.; Pleural Medicine Unit, Institute for Respiratory Health, Perth, WA 6009, Australia; Medical School, Faculty of Health & Medical Sciences, University of Western Australia, Perth, WA 6009, Australia; Grupo de Pesquisa em Exercício para Populações Clínicas (GPCLIN), Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul 95070-560, Brazil.; London Sport Institute, School of Science and Technology, Middlesex University, London, NW4 4BT, UK.; Department of Pathophysiology and Transplantation, University of Milan, Milan 20133, Italy.; Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia; School of Human Movement and Nutrition Sciences, University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: [email protected].

DOI: 10.1016/j.jshs.2024.04.005

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MeSH Terms: Adult, Humans, Decorin, Exercise, Fibronectins, Interleukin-15, Muscle, Skeletal, Myokines, Oncostatin M, Osteonectin, Resistance Training