The effects of ursolic acid on cardiometabolic risk factors: a systematic review and meta-analysis.

Reyhaneh Rabiee, Niloufar Rasaei, Zahra Kalantar, Pegah Rafiee, Mohammad Reza Amini, Fatemeh Sheikhhossein, Azita Hekmatdoost, Mohammad Gholizadeh

Journal: Future cardiology 2024;20(3):151-161

PMID: 38923885

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Abstract

Ursolic acid (UA) has an important biological role in the fight against fat accumulation, insulin resistance, obesity and inflammation. Therefore, in the current review and meta-analysis work, we investigate the effects of UA (dosage range is 50.94 to 450 mg/day) on cardiometabolic risk factors. After searching the studies up to February 2023, six articles were included in the study. The pooled effect size showed that UA supplementation didn't significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglyceride and high-density lipoprotein compared with control groups. UA supplementation had no significant effect on the cardiometabolic risk factors in adults.

Address: Student Research Committee, Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences & Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, 1981619573, Iran.; Department of Community Nutrition, School of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, 14155-6117, Iran.; Network of Interdisciplinarity in Neonates & Infants (NINI), Universal Scientific Education & Research Network (USERN), Tehran, 14155-6117, Iran.; Student Research Committee, Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences & Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, 1981619573, Iran.; Nutrition & Food Security Research Center & Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, 1981619573, Iran.; Student Research Committee, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, 8915173160, Iran.; Department of Clinical Nutrition, School of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences, Tehran, 14155-6117, Iran.; Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences & Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, 1981619573, Tehran,Iran.

DOI: 10.1080/14796678.2024.2349476

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MeSH Terms: Humans, Body Mass Index, Cardiometabolic Risk Factors, Cardiovascular Diseases, Dietary Supplements, Triterpenes, Ursolic Acid