Anti-inflammatory and immunomodulatory properties of polysaccharides in mushrooms.

Masashi Mizuno, Ken-Ichiro Minato

Journal: Current opinion in biotechnology 2024;86():103076

PMID: 38364705

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Abstract

Mushrooms are distinguished as important food-containing polysaccharides possessing potent anti-inflammatory and immunomodulating properties. These compounds belong mostly to polysaccharides that are mostly β-D-glucans. Among them, β-1,3-glucan with β-1,6 side chains of glucose residues, has more important roles in their properties. In this review, we have introduced polysaccharides mainly from Lentinula edodes and Pleurotus citrinopileatus with anti-inflammatory and immunomodulating properties. In addition, the mechanisms of activation of their physiological properties and signal cascade are also reviewed.

Address: Department of Health and Nutrition, Faculty of Human Science, Osaka Aoyama University, 2-11-1 Niina, Minoh, Osaka 562-8580, Japan. Electronic address: [email protected].; Department of Applied Biological Chemistry, The Graduate School of Agriculture, Meijo University, Nagoya 468-8502, Japan.

DOI: 10.1016/j.copbio.2024.103076

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MeSH Terms: Agaricales, Polysaccharides, Shiitake Mushrooms, Anti-Inflammatory Agents