Tricarboxylic acid cycle metabolites: new players in macrophage.

Jing-Yi Wang, Jun Xu, Ying Yang, Jian Li, Bing-Bing Cui, Jiao-Jiao Shan, Cheng-Yong Zhang, Xiao-Tong Wei, Ri-Ran Zhu

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024;73(4):531-539

PMID: 38498178

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Abstract

Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid (TCA) cycle metabolites in the innate immune system. In the current review, we summarize recent advances in the metabolic reprogramming of the TCA cycle during macrophage activation and polarization and address the effects of these metabolites in modulating macrophage function. Deciphering the crosstalk between the TCA cycle and the immune response might provide novel potential targets for the intervention of immune reactions and favor the development of new strategies for the treatment of infection, inflammation, and cancer.

Address: Department of Pharmacy, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.; Department of Traditional Chinese Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.; Department of Pharmacy, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China. [email protected].; Department of Hematology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China. [email protected].; Institute of Hematology, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China. [email protected].; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, Health Commission of Shandong Province, Jinan, 250014, China. [email protected].

DOI: 10.1007/s00011-024-01853-0

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https://dx.doi.org/10.1007/s00011-024-01853-0

MeSH Terms: Citric Acid Cycle, Macrophages