Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties.

Abdulrahim A Alzain, Hossam M Abdallah, Bayan E Ainousah, Sabrin R M Ibrahim, Gamal A Mohamed, Shaimaa G A Mohamed, Ahmed Ashour, Hazem G A Hussein

Journal: Archives of microbiology 2024;206(5):216

PMID: 38619638

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Abstract

Fungi are of considerable importance due to their capacity to biosynthesize various secondary metabolites with bioactive properties that draw high attention in new drug discovery with beneficial uses for improving human well-being and life quality. Aspergillus genus members are widespread and cosmopolitan species with varying economic significance in the fields of industry, medicine, and agriculture. Its species are renowned for their biosynthesis of secondary metabolites, characterized by both potent biological activity and structural novelty, making them a substantial reservoir for the development of new pharmaceuticals. The current work aimed at focusing on one species of this genus, Aspergillus wentii Wehmer, including its reported secondary metabolites in the period from 1951 to November 2023. A total of 97 compounds, including nitro-compounds, terpenoids, anthraquinones, xanthones, benzamides, and glucans. A summary of their bioactivities, as well as their biosynthesis was highlighted. Additionally, the reported applications of this fungus and its enzymes have been discussed. This review offers a useful reference that can direct future research into this fungus and its active metabolites, as well as their possible pharmacological and biotechnological applications.

Address: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Umm Al-Qura University, 21955, Makkah, Saudi Arabia.; Preparatory Year Program, Department of Chemistry, Batterjee Medical College, 21442, Jeddah, Saudi Arabia. [email protected].; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt. [email protected].; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Medani, Gezira, Sudan.; Faculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo, 11837, Egypt.; Preparatory Year Program, Batterjee Medical College, 21442, Jeddah, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.

DOI: 10.1007/s00203-024-03934-4

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https://dx.doi.org/10.1007/s00203-024-03934-4

MeSH Terms: Humans, Aspergillus, Agriculture, Anthraquinones, Benzamides