Five new eremophilane-type sesquiterpenes from the fresh roots of Rehmannia glutinosa.

Wei-Sheng Feng, Yan-Ling Liu, Xu Chen, Xiang-Da Li, Yan-Gang Cao, Yu-Han Zhang, Ying-Jie Ren, Meng-Nan Zeng, Xin-Yi Ma, Bing-Xian Zhao, Xiao-Ke Zheng

Journal: Fitoterapia 2024;175():105960

PMID: 38621426

Full Text on Elsevier Science View on PubMed

Abstract

Five undescribed eremophilane-type sesquiterpenes, remophilanetriols E-I (1-5), along with seven known compounds (6-12) were isolated from the fresh roots of Rehmannia glutinosa. Their structures were characterized by extensive spectroscopic data analysis and their absolute configurations were determined by comparing their calculated electronic circular dichroism (ECD) spectra and experimental ECD spectra. The anti-pulmonary fibrosis activities of all compounds were evaluated in vitro by MTT methods, and compounds 2, 8, 10, and 12 exhibited excellent anti-pulmonary fibrosis activities. In addition, compound 2 can reduce the levels of ROS and apoptosis in TGF-β1-induced BEAS-2B cells.

Address: School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Construction by Henan province & Education Ministry of P. R. China, Zhengzhou 450046, China. Electronic address: [email protected].; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Construction by Henan province & Education Ministry of P. R. China, Zhengzhou 450046, China. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2024.105960

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MeSH Terms: Plant Roots, Molecular Structure, Rehmannia, Humans, Phytochemicals, Sesquiterpenes, Apoptosis, Cell Line, Reactive Oxygen Species, China, Polycyclic Sesquiterpenes