PET/Computed Tomography Transformation of Oncology: Ovarian Cancers.

Grace Ho, Elaine Yuen Phin Lee, Pun Ching Philip Ip, Ka Yu Tse, Shuk Tak Kwok, Wan Kam Chiu

Journal: PET clinics 2024;19(2):207-216

PMID: 38177053

Full Text on Elsevier Science View on PubMed

Abstract

Over the last quarter of a century, fluorine-18-fluorodeoxyglucose (FDG) PET/computed tomography (CT) has revolutionized the diagnostic algorithm of ovarian cancer, impacting on the initial disease evaluation including staging and surgical planning, treatment response assessment and prognostication, to the most important role in detection of recurrent disease. The role of FDG PET/CT is expanding with the adoption of new therapeutic agents. Other non-FDG tracers have been explored with fibroblast activation protein inhibitor being promising. Novel tracers may provide the basis for future theragnostic work. This article will review the evolution and impact of PET/CT in ovarian cancer management.

Address: Department of Diagnostic Radiology, School of Clinical Medicine, University of Hong Kong, Room 406, Block K, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China. Electronic address: [email protected].; Department of Pathology, School of Clinical Medicine, University of Hong Kong, Room 019, 7/F, Block T, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China.; Department of Obstetrics and Gynaecology, School of Clinical Medicine, University of Hong Kong, 6/F, Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China.; Department of Obstetrics and Gynaecology, 6/F, Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China.; Department of Obstetrics and Gynaecology, United Christian Hospital, 5/F, Block S, Kwun Tong, Kowloon, Hong Kong, China.; Department of Radiology, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China.

DOI: 10.1016/j.cpet.2023.12.007

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MeSH Terms: Humans, Female, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Tomography, X-Ray Computed, Ovarian Neoplasms, Positron-Emission Tomography, Neoplasm Staging