Management of Extraocular Retinoblastoma: ICMR Consensus Guidelines.

Suyash Kulkarni, Girish Chinnaswamy, Tanvir Kaur, Rachna Meel, Lata Singh, Sameer Bakhshi, Venkatraman Radhakrishnan, Jyoti Sharma, Renu Madan, Archana Sasi, R S Dhaliwal, Meena Haldorai, Gaura Kishore Rath

Journal: Indian journal of pediatrics 2024;91(11):1157-1165

PMID: 38639859

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Abstract

Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Advanced stage presentation of RB is common in low middle-income countries (LMICs) due to lack of awareness, social taboos associated with enucleation, seeking alternative conservative treatment options, and poor accessibility to health care. Over the last few decades, there have been significant advancements in the management of extraocular RB (EORB) which have improved outcomes and helped in minimizing treatment-related toxicities. The incorporation of multimodality approaches including chemotherapy, surgery, and radiotherapy (RT) has shown promising results; however, prognosis remains poor especially in LMICs. In this article, authors have discussed the ICMR consensus guidelines on the management of EORB, including metastatic RB.

Address: Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.; Department of Medical Oncology and Pediatric Oncology, Cancer Institute (W.I.A), Adyar, Chennai, India. [email protected].; Department of Oculoplasty and Oncology Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.; Department of Pediatric Oncology, Tata Memorial Hospital, Parel, Mumbai, India.; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.; Department of Interventional Radiology, Tata Memorial Hospital, Parel, Mumbai, India.; Department of Medical Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.; Division of Non-Communicable Diseases (NCD Division), Indian Council of Medical Research (ICMR), New Delhi, India.; Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.; Former Head NCI and Chief, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

DOI: 10.1007/s12098-024-05104-2

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https://dx.doi.org/10.1007/s12098-024-05104-2

MeSH Terms: Humans, Combined Modality Therapy, Consensus, Retinal Neoplasms, Retinoblastoma