Recent Research Trends against Skin Carcinoma - An Overview.

Anjna Rani, Navneet Khurana, Rupa Mazumder, Rashmi Mishra, Kamya Varshney

Journal: Current pharmaceutical design 2024;30(34):2685-2700

PMID: 39051578

Abstract

Skin cancer is a prevalent and sometimes lethal cancer that affects a wide range of people. UV radiation exposure is the main cause of skin cancer. Immunosuppression, environmental factors, and genetic predisposition are other contributing variables. Fair-skinned people and those with a history of sunburns or severe sun exposure are more likely to experience this condition. Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) are the three main forms. Melanoma poses a bigger hazard because of its tendency for metastasis, while SCC and BCC have limited metastatic potential. Genetic mutations and changes to signalling pathways such as p53 and MAPK are involved in pathogenesis. Early diagnosis is essential, and molecular testing, biopsy, dermoscopy, and visual inspection can all help. In addition to natural medicines like curcumin and green tea polyphenols, treatment options include immunotherapy, targeted therapy, radiation, surgery, and chemotherapy. Reducing the incidence of skin cancer requires preventive actions, including sun protection and early detection programs. An overview of skin cancers, including their forms, pathophysiology, diagnosis, and treatment, highlighting herbal therapy, is given in this review.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Address: Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh 201306, India.; Department of Biotechnology, Noida Institute of Engineering and Technology, Greater Noida, Uttar Pradesh 201306, India.; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

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