Integrating network pharmacology: The next-generation approach in ocular drug discovery.

Federica Conti, Chiara Bianca Maria Platania, Francesca Lazzara, Filippo Drago, Claudio Bucolo, Erika Giuffrida, Chiara Maria Eandi

Journal: Current opinion in pharmacology 2024;74():102425

PMID: 38183849

Abstract

With the spread of the "omics" sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can be used for the design of biologic networks, that in turn can be quantitatively analyzed to identify new pharmacological targets. In this review, we will introduce the concept of network pharmacology, particularly the application of this innovative approach in the field of ocular pharmacology, with a focus on retinal diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma.

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Address: Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.; Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland; Department of Surgical Science, University of Torino, Torino, Italy.; Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy; Center for Research in Ocular Pharmacology-CERFO, University of Catania, Catania, Italy.; Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy; Center for Research in Ocular Pharmacology-CERFO, University of Catania, Catania, Italy. Electronic address: [email protected].
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