The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease.

Andrew C Nixon, James Tollitt, Lynda Haggis, Vashist Deelchand, Nicola Cooper, Christy Walklin, Juliet Briggs, Sunil Bhandari, Helen Noble, Thomas J Wilkinson, James O Burton, David C Wheeler, Philip A Kalra, Maarten W Taal, Hannah M L Young, Jackie Campbell, Matthew P M Graham-Brown, Roseanne E Billany, Zoe L Saynor, Nicolette Bishop, Ellen M Castle, Alexander Hamilton, Kieran McCafferty, Sharlene A Greenwood, Joseph Chilcot, Kate Bramham, Elham Asgari, Jamie Macdonald, Mark Jesky, Pelagia Koufaki

Journal: Scientific reports 2024;14(1):700

PMID: 38184737

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Abstract

This trial assessed the feasibility and acceptability of Kidney BEAM, a physical activity and emotional well-being self-management digital health intervention (DHI) for people with chronic kidney disease (CKD), which offers live and on-demand physical activity sessions, educational blogs and videos, and peer support. In this mixed-methods, multicentre randomised waitlist-controlled internal pilot, adults with established CKD were recruited from five NHS hospitals and randomised 1:1 to Kidney BEAM or waitlist control. Feasibility outcomes were based upon a priori progression criteria. Acceptability was primarily explored via individual semi-structured interviews (n = 15). Of 763 individuals screened, n = 519 (68%, 95% CI 65 to 71%) were eligible. Of those eligible, n = 303 (58%, 95% CI 54-63%) did not respond to an invitation to participate by the end of the pilot period. Of the 216 responders, 50 (23%, 95% CI 18-29%) consented. Of the 42 randomised, n = 22 (10 (45%) male; 49 ± 16 years; 14 (64%) White British) were allocated to Kidney BEAM and n = 20 (12 (55%) male; 56 ± 11 years; 15 (68%) White British) to the waitlist control group. Overall, n = 15 (30%, 95% CI 18-45%) withdrew during the pilot phase. Participants completed a median of 14 (IQR 5-21) sessions. At baseline, 90-100% of outcome data (patient reported outcome measures and a remotely conducted physical function test) were completed and 62-83% completed at 12 weeks follow-up. Interview data revealed that remote trial procedures were acceptable. Participants' reported that Kidney BEAM increased their opportunity and motivation to be physically active, however, lack of time remained an ongoing barrier to engagement with the DHI. An randomised controlled trial of Kidney BEAM is feasible and acceptable, with adaptations to increase recruitment, retention and engagement.Trial registration NCT04872933. Date of first registration 05/05/2021.

Address: Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester, UK. [email protected].; Diabetes Research Centre, University of Leicester, Leicester, UK. [email protected].; National Institute of Health Research Leicester Biomedical Research Centre, Leicester, UK. [email protected].; School of Physiotherapy, Department of Health Sciences, Brunel University, London, UK.; Renal Department, King's College Hospital, London, UK.; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; Department of Nephrology, Guys and St Thomas's Hospital, London, UK.; Department of Nephrology, Hull University Teaching Hospitals NHS Trust, Hull, UK.; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.; Faculty of Health, Education and Society, University of Northampton, Northampton, UK.; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Department of Population Health Science, University of Leicester, Leicester, UK.; Department of Nephrology Royal Free Hospital, London, UK.; Department of Nephrology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Department of Nephrology, Nottingham NHS Trust, Nottingham, UK.; Department of Nephrology Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.; Dietetics, Nutrition & Biological Sciences, Physiotherapy, Podiatry & Radiography Division, Queen Margaret University, Edinburgh, UK.; Institute for Applied Human Physiology, Bangor University, Bangor, UK.; Department of Nephrology, Barts Health NHS Trust, London, UK.; Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.; Division of Cardiovascular Sciences, The University of Manchester, Manchester, UK.; School of Nursing and Midwifery, Queen's University Belfast, Belfast, UK.; School of Sport, Health and Exercise Science, University of Portsmouth, Portsmouth, UK.; Centre for Kidney Research and Innovation, University of Nottingham, Nottingham, UK.; Department of Renal Medicine, University College London, London, UK.; National Institute of Health Research Leicester Biomedical Research Centre, Leicester, UK.

DOI: 10.1038/s41598-023-50507-4

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MeSH Terms: Adult, Female, Humans, Male, Blogging, Exercise, Kidney, Pilot Projects, Renal Insufficiency, Chronic, Middle Aged, Aged