Programme Dementia Prevention (pdp): A Nationwide Program for Personalized Prevention in Luxembourg.

Richard Dodel, Patricia Martins Conde, Ruxandra Soare, Margarita Reyes, Sophie Wagner, Sabine K Schmitz, Deborah McIntyre, Joao M Loureiro, Joëlle V Fritz, Anne Kaysen, Amna Skrozic, Valerie E Schröder, Elke Kalbe, Laure Pauly, Sebastian Köhler, Dorothee Erz, Tobias Hartmann, Rejko Krüger, Kirsten Roomp, Jochen Klucken, Carlos Vega, Venkata Satagopam, Piotr Gawron, Anja K Leist, Jennifer Kemp

Journal: Journal of Alzheimer's disease : JAD 2024;97(2):791-804

PMID: 38189752

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Abstract

BACKGROUND

With continuously aging societies, an increase in the number of people with cognitive decline is to be expected. Aside from the development of causative treatments, the successful implementation of prevention strategies is of utmost importance to reduce the high societal burden caused by neurodegenerative diseases leading to dementia among which the most common cause is Alzheimer's disease.

OBJECTIVE

The aim of the Luxembourgish "programme dementia prevention (pdp)" is to prevent or at least delay dementia in an at-risk population through personalized multi-domain lifestyle interventions. The current work aims to provide a detailed overview of the methodology and presents initial results regarding the cohort characteristics and the implementation process.

METHODS

In the frame of the pdp, an extensive neuropsychological evaluation and risk factor assessment are conducted for each participant. Based on the results, individualized multi-domain lifestyle interventions are suggested.

RESULTS

A total number of 450 participants (Mean age = 69.5 years; SD = 10.8) have been screened at different recruitment sites throughout the country, among whom 425 participants (94.4%) met the selection criteria.

CONCLUSIONS

We provide evidence supporting the feasibility of implementing a nationwide dementia prevention program and achieving successful recruitment of the target population by establishing a network of different healthcare providers.

Address: Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Department of Neurology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.; Department of Neurology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Department of Neurology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Department of Geriatrics, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Digital Medicine, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.; Digital Medicine, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.; Alzheimer Centrum Limburg, School for Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands.; Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.; Deutsches Institut für Demenz Prävention (DIDP), Medical Faculty, Saarland University, Homburg, Germany.; Department of Experimental Neurology, Saarland University, Homburg, Germany.; Chair of Geriatric Medicine, University Duisburg-Essen, Essen, Germany.; Institute for Research on Socio-Economic Inequality (IRSEI), University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Department of Medical Psychology | Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Intervention (CeNDI), Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Department of Neurology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.

DOI: 10.3233/JAD-230794