The effect of vitamin D status on the occurrence of Kawasaki Disease: a meta-analysis.

Fuyong Jiao, Jiaojiao Wang, Kejin Zhang, Haixiang Zhang, Cuixiang Xu

Journal: BMC pediatrics 2024;24(1):287

PMID: 38684993

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Abstract

AIM

The relationship between vitamin D status and Kawasaki Disease (KD), as well as coronary artery lesion (CAL), has yet to be established.

METHODS

A meta-analysis was conducted to assess the correlation between vitamin D status and KD, as well as the impact of vitamin D status on the progression of KD into CAL.

RESULTS

The meta-analysis revealed a consistent and significant association between serum 25(OH)D level and the occurrence KD (studies N = 22; z = -3.51, P < 0.001). Patients with KD had markedly lower levels of vitamin D than healthy controls (SMD: -1.30 ng/mL, 95%CI: -2.05 to -0.55 ng/mL).

CONCLUSION

The study provided evidence supporting a significant association between lower serum vitamin D levels and the occurrence of KD, particularly within the Chinese population. However, the findings did not suggest a direct impact of vitamin D on the development of CAL in KD patients.

Address: Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 256# Youyi West Road, Xi'an, Shaanxi, 710068, China.; Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.; Shaanxi Provincial Kawasaki Disease Treatment Center/Children's Hospital of Shaanxi Provincial People's Hospital, Xi'an, 710068, China.; Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 256# Youyi West Road, Xi'an, Shaanxi, 710068, China.; Department of Medicine, School of Medicine, Yan'an University, Yan'an, 716000, China.; Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 256# Youyi West Road, Xi'an, Shaanxi, 710068, China. [email protected].; Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China. [email protected].; Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 256# Youyi West Road, Xi'an, Shaanxi, 710068, China. [email protected].; Department of Biological Sciences, College of Life Science, Institute of Population and Health, Northwest University, Xi'an, 710069, China. [email protected].

DOI: 10.1186/s12887-024-04768-1

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https://medlineplus.gov/vitamind.html

MeSH Terms: Mucocutaneous Lymph Node Syndrome, Humans, Vitamin D, Vitamin D Deficiency, Coronary Artery Disease, Disease Progression