Modeling stability of photoheterotrophic continuous cultures in photobioreactors.

Jean-François Cornet, Lidia Favier, Claude-Gilles Dussap

Journal: Biotechnology progress 2004;19(4):1216-27

PMID: 12892484

Abstract

Continuous cultures of the purple non-sulfur bacterium Rhodospirillum rubrum were grown in a cylindrical photobioreactor in photoheterotrophic conditions, using acetate as carbon source. A new kinetic and stoichiometric knowledge model was developed, and its ability to simulate experimental results obtained under varying incident light fluxes and residence times is discussed. The model accurately predicts the stable, unstable, or oscillating behavior observed for the reactor productivity. In particular, the values of residence time corresponding to a subcritical bifurcation with a typical hysteresis effect are calculated and analyzed. The robustness of the proposed model allows the engineering operating domain of the photobioreactor function to be set and offers a promising tool for the design and control of such photoheterotrophic processes.

Address: Laboratoire de Génie Chimique et Biochimique, Université Blaise Pascal-CUST 24, avenue des Landais, BP 206, F 63174 AUBIERE Cedex, France.

DOI: 10.1021/bp034041l

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MeSH Terms: Acetates, Bioreactors, Cell Culture Techniques, Cell Division, Computer Simulation, Dose-Response Relationship, Radiation, Homeostasis, Light, Models, Biological, Nonlinear Dynamics, Photobiology, Reproducibility of Results, Rhodospirillaceae, Sensitivity and Specificity