Therapeutic potential of lipid-lowering probiotics on the atherosclerosis development.

Fatemeh Forouzanfar, Ehsan Saburi, Seyed-Alireza Esmaeili, Mohamed J Saadh, Behina Bazghandi, Hamid Jamialahmdi, Fatemeh Rahimzadeh-Bajgiran

Journal: European journal of pharmacology 2024;971():176527

PMID: 38554932

Full Text on Elsevier Science View on PubMed

Abstract

Hypercholesterolemia is a critical risk factor for atherosclerosis, mostly attributed to lifestyle behavior such as diet. Recent advances have emphasized the critical effects of gastrointestinal bacteria in the pathology of hypercholesterolemia and atherosclerosis, suggesting that the gastrointestinal microbiome can therefore provide efficient therapeutic targets for preventing and treating atherosclerosis. Thus, interventions, such as probiotic therapy, aimed at altering the bacterial composition introduce a promising therapeutic procedure. In the current review, we will provide an overview of anti-atherogenic probiotics contributing to lipid-lowering, inhibiting atherosclerotic inflammation, and suppressing bacterial atherogenic metabolites.

Address: Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan. Electronic address: [email protected].; Protein Research Center, Shahid Beheshti University, Tehran, Iran. Electronic address: [email protected].; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].; Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. Electronic address: [email protected].; Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran. Electronic address: [email protected].; Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].

DOI: 10.1016/j.ejphar.2024.176527

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MeSH Terms: Humans, Hypercholesterolemia, Cholesterol, Atherosclerosis, Probiotics, Hyperlipidemias