RUTIN, a widely consumed flavonoid, that commonly induces hormetic effects.

Peter Pressman, Edward J Calabrese, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese, A Wallace Hayes, Evgenios Agathokleous

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024;187():114626

PMID: 38556157

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Abstract

Rutin is a flavonoid present in numerous fruits and vegetables and therefore widely consumed by humans. It is also a popular dietary supplement of 250-500 mg/day. There is considerable consumer interest in rutin due to numerous reports in the biomedical literature of its multi-system chemo-preventive properties. The present paper provides the first assessment of rutin-induced hormetic concentration/dose responses, their quantitative features and mechanistic basis, along with their biological, biomedical, clinical, and public health implications. The findings indicate that rutin-induced hormetic dose responses are widespread, being reported in numerous biological models and cell types for a wide range of endpoints. Of critical importance is that the optimal hormetic findings shown in in vitro systems are currently not achievable for human populations due to low gastrointestinal tract bioavailability. These findings have the potential to strengthen future experimental studies with rutin, particularly concerning study design parameters.

Address: School of Public Health and Health Sciences, Department of Environmental Health, Morrill I-N344, University of Massachusetts, Amherst, MA, 01003, USA. Electronic address: [email protected].; University of Maine, 5728 Fernald Hall, Room 201, Orono, ME, 04469, USA. Electronic address: [email protected].; Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, FL, USA. Electronic address: [email protected].; Sri Guru Ram Das (SGRD), University of Health Sciences, Amritsar, India. Electronic address: [email protected].; Saint Francis Hospital and Medical Center, Hartford, CT, USA. Electronic address: [email protected].; School of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, China. Electronic address: [email protected].; Department of Biomedical and Biotechnological Sciences, School of Medicine University of Catania, Via Santa Sofia 97, Catania, 95123, Italy. Electronic address: [email protected].

DOI: 10.1016/j.fct.2024.114626

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MeSH Terms: Humans, Hormesis, Rutin, Flavonoids, Models, Biological, Vegetables