The Multitarget Action of Vitamins in the Ischemic Stroke.

Pablo Rayff da Silva, Marcus T Scotti, Alex France M Monteiro, Luciana Scotti, Rodrigo Santos Aquino de Araújo, Vanessa Lima do Nascimento, Kadja Luana Chagas Monteiro, Thiago Mendonça de Aquino, Wadja Feitosa Dos Santos Silva, Edeildo Ferreira da Silva Junior, Francisco Jaime Bezerra Mendonça Junior

Journal: Current topics in medicinal chemistry 2024;24(28):2465-2488

PMID: 39301898

Full Text on Bentham Science Publishers Ltd. View on PubMed

Abstract

A stroke, also known as a cerebral hemorrhage, occurs when there is an interruption in the blood supply to a part of the brain, resulting in damage to brain cells. This issue is one of the leading causes of death in developed countries, currently killing about 5 million people annually. Individuals who survive ischemic stroke often face serious vision problems, paralysis, dementia, and other sequelae. The numerous efforts to prevent and/or treat stroke sequelae seem insufficient, which is concerning given the increasing global elderly population and the well-known association between aging and stroke risk. In this review, we aim to present and discuss the importance of vitamins in stroke prevention and/or incidence. Vitamins from diet or dietary supplements influence the body at various levels; they are a relevant factor but are reported only in isolated articles. This review reports and updates the multitarget role of vitamins involved in reducing stroke risk.

Address: Post-Graduate Program in Natural and Synthetic Bioactive Compounds, Federal University of Paraíba (UFPB), João Pessoa, Paraiba, Brazil.; Postgraduate Program in Dentistry, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.; Post-Graduate Program in Natural and Synthetic Bioactive Compounds, Federal University of Paraíba (UFPB), João Pessoa, Paraiba, Brazil.; Postgraduate Program in Chemistry, Department of Chemistry, Federal Rural University of Pernambuco, Campus I-Recife/PE, Brazil.; Laboratory of Synthesys and Drug Delivery - LSVM, State University of Paraíba (UEPB), João Pessoa, Brazil.; Research Group on Therapeutic Strategies - GPET, Institute of Chemistry and Biotechnology, Federal University of Alagoas (UFAL), Maceió, Brazil.; Post-Graduate Program in Natural and Synthetic Bioactive Compounds, Federal University of Paraíba (UFPB), João Pessoa, Paraiba, Brazil.; Laboratory of Synthesys and Drug Delivery - LSVM, State University of Paraíba (UEPB), João Pessoa, Brazil.

DOI: 10.2174/0115680266316939240909070627

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https://medlineplus.gov/ischemicstroke.html

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https://www.eurekaselect.com/234229/article

MeSH Terms: Humans, Vitamins, Ischemic Stroke, Dietary Supplements, Stroke