VCAM-1-targeted nanoparticles to diagnose, monitor and treat atherosclerosis.

Andrea M Mastro, Rita Castro, James H Adair, Thomas Neuberger, Gail L Matters

Journal: Nanomedicine (London, England) 2024;19(8):723-735

PMID: 38420919

Abstract

Vascular cell adhesion molecule-1 (VCAM-1) was identified over 2 decades ago as an endothelial adhesion receptor involved in leukocyte recruitment and cell-based immune responses. In atherosclerosis, a chronic inflammatory disease of the blood vessels that is the leading cause of death in the USA, endothelial VCAM-1 is robustly expressed beginning in the early stages of the disease. The interactions of circulating immune cells with VCAM-1 on the activated endothelial cell surface promote the uptake of monocytes and the progression of atherosclerotic lesions in susceptible vessels. Herein, we review the role of VCAM-1 in atherosclerosis and the use of VCAM-1 binding peptides, antibodies and aptamers as targeting agents for nanoplatforms for early detection and treatment of atherosclerotic disease.

Address: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Pharmaceutical Sciences & Medicines, Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisboa, Portugal.; Department of Materials Science, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Pharmacology, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.; Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA.

DOI: 10.2217/nnm-2023-0282

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https://www.tandfonline.com/doi/10.2217/nnm-2023-0...

MeSH Terms: Humans, Vascular Cell Adhesion Molecule-1, Atherosclerosis, Peptides, Cell Membrane, Nanoparticles, Endothelium, Vascular, Cell Adhesion