Oral Surgery and Dental Implants in Patients with Chronic Kidney Disease: Scoping Review for Oral Health Status.

Felice Lorusso, Alberta Greco Lucchina, Carmen Mortellaro, Francesco Inchingolo, Antonio Scarano, Iris Alla, Sergio Alexandre Gehrke, Sergio Rexhep Tari

Journal: Discovery medicine 2024;36(184):874-881

PMID: 38798248

Abstract

The number of chronic kidney disease (CKD) patients requiring renal replacement therapy is increasing, often exhibiting oral manifestations including periodontal disease, gingival hyperplasia, altered saliva composition, and uremic stomatitis. Uremic stomatitis, xerostomia, and candidiasis are very frequent, particularly among patients undergoing dialysis or kidney transplant recipients. CKD patients also experience profound alterations in bone metabolism inherent in the homeostasis of calcium, phosphorus, vitamin D, parathyroid hormone, and fibroblast growth factor (FGF). These alterations lead to demineralization of the jaw bones, reduced bone trabeculae, reduced cortical bone thickness, fibrocystic bone lesions, bone fractures, and delayed wound healing post-tooth extraction. Consequently, oral health management of elderly hemodialysis patients poses serious clinical problems. This review focused on the oral health and rehabilitation of patients with CKD or on dialysis.

Address: Department of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.; Research Laboratory in Regenerative Medicine and Tissue Engineering, Saint Camillus, International University of Health Sciences, 00131 Rome, Italy.; Department of Research, Bioface/PgO/UCAM, 11100 Montevideo, Uruguay.; Department of Biotechnology, Universidad Católica de Murcia (UCAM), 30107 Murcia, Spain.; Department of Interdisciplinary Medicine, Section of Dentistry, University of Bari School of Medicine, 70124 Bari, Italy.
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