Metabolomics of male infertility.

Amos Victor Oluwaloseyi, Odeyemi Aduragbemi Noah, Ajayi Lydia Oluwatoyin, Yusuff Gaffar, Olotu Moses, Akano Oyedayo Phillips, Moyinoluwa Comfort Onaolapo, Bolade Sylvester Olateju, Adelakun Ademola Ayodele, Oyowvi Mega Obukohwo, Ajayi Ayodeji Folorunsho

Journal: Clinica chimica acta; international journal of clinical chemistry 2024;556():117850

PMID: 38431200

Full Text on Elsevier Science View on PubMed

Abstract

This review explores the use of metabolomics in male infertility. Metabolomics, an evolving omics technology that targets the products of cellular metabolism, is valuable for elucidating underlying pathophysiology of many disorders including male infertility. The identification of reliable biomarkers is essential for accurate diagnosis and for developing precision therapeutics for those afflicted by reproductive dysfunction. Unfortunately, despite significant progress to date, the intricate relationships between these metabolic pathways and male infertility remain elusive. It is clear, however, that additional research is required to more fully characterize the role of metabolomics in this disorder and in the potential development of targeted therapies for precision medicine.

Address: Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria; Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Department of Physiology, Babcock University, Ilishan Remo, Ogun State, Nigeria.; Department of Nutrition and Integrative Physiology, Florida State University, USA.; Department of Medical Laboratory Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Department of Physiology, Adeleke University, Ede, Osun State, Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria; Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria; Department of Physiology, Adeleke University, Ede, Osun State, Nigeria. Electronic address: [email protected].

DOI: 10.1016/j.cca.2024.117850

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MeSH Terms: Humans, Male, Infertility, Male, Biomarkers, Metabolomics, Precision Medicine