Functions of mucosal associated invariant T cells in eye diseases.

Atsunobu Takeda, Hiroki Tsutsui, Takako Ito, Koh-Hei Sonoda, Chihiro Fukui, Satoshi Yamana, Yanqi Xue, Mariko Shirane, Kenichiro Asahara, Keiko Yoshitomi, Tantri Lestari, Eiichi Hasegawa, Nobuyo Yawata, Kensuke Shibata

Journal: Frontiers in immunology 2024;15():1341180

PMID: 38440736

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Abstract

Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells in cancer, autoimmunity, and infectious diseases has been rapidly expanding. Recently, MAIT cells have been found to contribute to visual protection against autoimmunity in the eye. The protective functions of MAIT cells are induced by T-cell receptor (TCR)-mediated activation. However, the underlying mechanisms remain unclear. Thus, this mini-review aims to discuss our findings and the complexity of MAIT cell-mediated immune regulation in the eye.

Address: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.; Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.

DOI: 10.3389/fimmu.2024.1341180

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https://medlineplus.gov/eyediseases.html

MeSH Terms: Humans, Mucosal-Associated Invariant T Cells, Eye Diseases, Autoimmunity, Riboflavin