Lipid droplets and cellular lipid flux.

James A Olzmann, Alyssa J Mathiowetz

Journal: Nature cell biology 2024;26(3):331-345

PMID: 38454048

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Abstract

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of lipid droplets in regulating fatty acid flux in lipotoxicity and cell death.

Address: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. [email protected].; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA. [email protected].; Chan Zuckerberg Biohub - San Francisco, San Francisco, CA, USA. [email protected].

DOI: 10.1038/s41556-024-01364-4

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https://doi.org/10.1038/s41556-024-01364-4

MeSH Terms: Lipid Droplets, Lipid Metabolism, Homeostasis, Fatty Acids