Liquid Biopsy: A Game Changer for Type 2 Diabetes.

Gratiela Gradisteanu Pircalabioru, Madalina Musat, Viviana Elian, Ciprian Iliescu

Journal: International journal of molecular sciences 2024;25(5):

PMID: 38473908

Abstract

As the burden of type 2 diabetes (T2D) continues to escalate globally, there is a growing need for novel, less-invasive biomarkers capable of early diabetes detection and monitoring of disease progression. Liquid biopsy, recognized for its minimally invasive nature, is increasingly being applied beyond oncology, and nevertheless shows its potential when the collection of the tissue biopsy is not possible. This diagnostic approach involves utilizing liquid biopsy markers such as cell-free nucleic acids, extracellular vesicles, and diverse metabolites for the molecular diagnosis of T2D and its related complications. In this context, we thoroughly examine recent developments in T2D liquid biopsy research. Additionally, we discuss the primary challenges and future prospects of employing liquid biopsy in the management of T2D. Prognosis, diagnosis and monitoring of T2D through liquid biopsy could be a game-changing technique for personalized diabetes management.

Address: eBio-Hub Research-Center, National University of Science and Technology "Politehnica" Bucharest, 6 Iuliu Maniu Bulevard, Campus Building, 061344 Bucharest, Romania.; Research Institute of University of Bucharest, University of Bucharest, 050095 Bucharest, Romania.; Academy of Romanian Scientists, 3 Ilfov Str., 050094 Bucharest, Romania.; eBio-Hub Research-Center, National University of Science and Technology "Politehnica" Bucharest, 6 Iuliu Maniu Bulevard, Campus Building, 061344 Bucharest, Romania.; Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, 030167 Bucharest, Romania.; Department of Endocrinology, C.I. Parhon National Institute of Endocrinology, 011683 Bucharest, Romania.; Department of Diabetes, Nutrition and Metabolic Diseases, Carol Davila University of Medicine and Pharmacy, 5-7 Ion Movila Street, 030167 Bucharest, Romania.; Department of Diabetes, Nutrition and Metabolic Diseases, Prof. Dr. N. C. Paulescu National Institute of Diabetes, Nutrition and Metabolic Diseases, 030167 Bucharest, Romania.; eBio-Hub Research-Center, National University of Science and Technology "Politehnica" Bucharest, 6 Iuliu Maniu Bulevard, Campus Building, 061344 Bucharest, Romania.; Academy of Romanian Scientists, 3 Ilfov Str., 050094 Bucharest, Romania.; National Research and Development Institute in Microtechnologies-IMT Bucharest, 126A Erou Iancu Nicolae Street, 077190 Voluntari, Romania.

DOI: 10.3390/ijms25052661

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/diabetestype2.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Humans, Diabetes Mellitus, Type 2, Biomarkers, Tumor, Liquid Biopsy, Extracellular Vesicles, Cell-Free Nucleic Acids, Neoplastic Cells, Circulating