Management of Poorly Differentiated Thyroid Cancer and Differentiated High-Grade Thyroid Carcinoma.

Kepal N Patel, Iram S Alam

Journal: The Surgical clinics of North America 2024;104(4):751-765

PMID: 38944496

Full Text on Elsevier Science View on PubMed

Abstract

Thyroid carcinoma of follicular cell origin exists on a histopathologic and clinical spectrum. The authors focus on the category of tumors that fall between the very favorable well-differentiated thyroid carcinomas and the very unfavorable anaplastic thyroid carcinomas. These intermediately aggressive tumors include poorly differentiated thyroid carcinoma and the newly defined differentiated high-grade thyroid carcinoma. Both diagnoses require certain histopathologic requirements be met in order to accurately identify these tumors post-operatively. Management remains primarily surgical though adjunctive treatments such as molecular targeted therapies (eg, tyrosine kinase inhibitors) and differentiation therapy (to restore tumor response to radioactive iodine) are also becoming available.

Address: Department of Surgery, NYU Langone Health, 530 First Avenue, 12th Floor, New York, NY 10016, USA. Electronic address: [email protected].; Faculty Development, Division of Endocrine Surgery, NYU Langone Health, 530 First Avenue, 12th Floor, New York, NY 10016, USA.

DOI: 10.1016/j.suc.2024.02.005

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MeSH Terms: Humans, Thyroid Neoplasms, Thyroidectomy, Neoplasm Grading, Adenocarcinoma, Follicular, Thyroid Carcinoma, Anaplastic