Natural products and derivatives in renal, urothelial and testicular cancers: Targeting signaling pathways and therapeutic potential.

Wuran Wei, Xing Ye, Chi Zhang, Dengxiong Li, Jie Wang, Ruicheng Wu, Zhouting Tuo, Qingxin Yu, Koo Han Yoo, Dechao Feng, Akira Miyamoto

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 2024;127():155503

PMID: 38490077

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Natural products have demonstrated significant potential in cancer drug discovery, particularly in renal cancer (RCa), urothelial carcinoma (UC), and testicular cancer (TC).

PURPOSE

This review aims to examine the effects of natural products on RCa, UC and TC.

STUDY DESIGN

systematic review METHODS: PubMed and Web of Science databases were retrieved to search studies about the effects of natural products and derivatives on these cancers. Relevant publications in the reference list of enrolled studies were also checked.

RESULTS

This review highlighted their diverse impacts on key aspects such as cell growth, apoptosis, metastasis, therapy response, and the immune microenvironment. Natural products not only hold promise for novel drug development but also enhance the efficacy of existing chemotherapy and immunotherapy. Importantly, we exert their effects through modulation of critical pathways and target genes, including the PI3K/AKT pathway, NF-κB pathway, STAT pathway and MAPK pathway, among others in RCa, UC, and TC.

CONCLUSION

These mechanistic insights provide valuable guidance for researchers, facilitating the selection of promising natural products for cancer management and offering potential avenues for further gene regulation studies in the context of cancer treatment.

Address: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.; Department of Urology, Kyung Hee University, South Korea.; Department of pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo City, Zhejiang Province, 315211, China.; Department of Rehabilitation, West Kyushu University, Japan.; Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, PR China.; Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: [email protected].; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: [email protected].; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, PR China. Electronic address: [email protected].

DOI: 10.1016/j.phymed.2024.155503

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MeSH Terms: Male, Humans, Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Phosphatidylinositol 3-Kinases, Testicular Neoplasms, Biological Products, Signal Transduction, Tumor Microenvironment, Neoplasms, Germ Cell and Embryonal