Polymorphisms in the human homologue of the drosophila Indy (I'm not dead yet) gene.

Pauline Lee, Ngoc Ho, Terri Gelbart, Ernest Beutler

Journal: Mechanisms of ageing and development 2004;124(8-9):897-902

PMID: 14499494

Full Text on Elsevier Science View on PubMed

Abstract

Insertion of a P element in one copy of the Drosophila Indy gene results in a significant increase in Drosophila lifespan. In order to examine whether mutations or polymorphisms in the human Indy gene promoted human longevity, the Indy gene was sequenced in 13 subjects of age 90-99, 12 subjects between age 38-49 and 18 subjects

Address: Division of Hematology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. [email protected]

DOI: 10.1016/s0047-6374(03)00149-0

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MeSH Terms: Adult, Aged, Aged, 80 and over, Amino Acid Substitution, Dicarboxylic Acid Transporters, Female, Gene Silencing, Haplotypes, Humans, Introns, Male, Middle Aged, Organic Anion Transporters, Sodium-Dependent, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Symporters