Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders.

Julia L M Dunn, Lisa A Spencer

Journal: Immunology and allergy clinics of North America 2024;44(2):299-309

PMID: 38575225

Full Text on Elsevier Science View on PubMed

Abstract

Eosinophilic gastrointestinal disorder (EGID) is an umbrella term encompassing a group of chronic, immune-mediated disorders characterized by eosinophil-rich inflammation affecting one or more segments of the gastrointestinal tract. A recent consensus in nomenclature and emerging data made possible through multi-center consortia are beginning to unravel the molecular and cellular underpinnings of EGIDs below the esophagus. These emerging findings are revealing both overarching commonalities related to a food allergen-driven, chronic, Th2-mediated immune response as well as location-specific nuances in the pathophysiology of the collective EGIDs. Altogether, these advances offer promise for improved diagnoses and more efficacious interventional strategies.

Address: Department of Pediatrics, Section of GI, Hepatology, and Nutrition, University of Colorado School of Medicine, and Digestive Health Institute, Children's Hospital Colorado, Aurora, CO 80045, USA.; Department of Pediatrics, Section of GI, Hepatology, and Nutrition, University of Colorado School of Medicine, and Digestive Health Institute, Children's Hospital Colorado, Aurora, CO 80045, USA. Electronic address: [email protected].

DOI: 10.1016/j.iac.2024.01.003

Link outs

Free resources

Medical:

https://medlineplus.gov/eosinophilicesophagitis.ht...

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Enteritis, Gastritis, Eosinophilia, Eosinophilic Esophagitis